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10% LMD
in 5% Dextrose Injection
DEXTRAN 40 IN DEXTROSE INJECTION, USP

EACH 100 mL CONTAINS 10g DEXTRAN 40, 5g DEXTROSE,
HYDROUS. 255 mOsmol/LITER (CALC.). pH 4.4 (3.0 TO 7.0)
STERILE, NONPYROGENIC.

ADDITIVE MEDICATIONS SHOULD NOT BE DELIVERED VIA
PLASMA VOLUME EXPANDERS.

SINGLE-DOSE CONTAINER. CONTAINS NO BACTERIOSTAT.
DISCARD UNUSED PORTION. FOR INTRAVENOUS USE.
USUAL DOSAGE: SEE INSERT. STORE AT 20 TO 25°C (68 TO
77°F). [SEE USP CONTROLLED ROOM TEMPERATURE.]
PROTECT FROM FREEZING. DO NOT USE IF
CRYSTALLIZATION HAS OCCURRED. USE ONLY IF SOLUTION
IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE
USED IN SERIES CONNECTIONS.

DESCRIPTION
LMD (dextran 40) is a sterile, nonpyrogenic preparation of low molecular weight dextran (average mol. wt. 40,000) in 5% Dextrose Injection or 0.9% Sodium Chloride Injection. It is administered by intravenous infusion.
Also described as low viscous or low viscosity dextran, dextran 40 is prepared by acid hydrolysis and The structural formula for dextran (repeating unit) is:
Dextrose, USP is chemically designated D-glucose monohydrate (C6 H12 O6 ? H2O), a hexose sugar freely soluble in water. Sodium Chloride, USP is chemically designated NaCl, a white crystalline powder freely soluble in water.
Water for Injection, USP is chemically designated H2O.
The flexible plastic container is fabricated from a specially formulatedpolyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions inside the plastic container also can leach out certain of the chemical components of the plastic in very small amounts before the expiration period is attained. However, safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers.

differential fractionation of a crude macromolecular polysaccharide produced from the fermentation of sucrose by the bacterium, Leuconostoc mesenteroides (strain B-512). The crude material is composed of linked glucose units. In the fraction represented by dextran 40, 80% of the molecules have a molecular weight ranging from 10,000 to 90,000 (average approximay 40,000) when measured by a light
scattering method. More than 90% of the linkages are of the 1,6 alpha glucosidic, straight chain type. Each 100 mL of 10% LMD (dextran 40) in 5% Dextrose Injection contains 10 g dextran 40 and 5 g dextrose hydrous in water for injection. Total osmolar concentration is 255 mOsmol/liter (calc.); pH is 4.4
(3.0 to 7.0). Each 100 mL of 10% LMD (dextran 40) in 0.9% Sodium Chloride Injection contains 10 g dextran 40 and 0.9 g sodium chloride in water for injection. Total osmolar concentration is 310 mOsmol/liter (calc.); pH is 4.9 (3.5 to 7.0) (may contain sodium hydroxide and/or hydrochloric acid for pH adjustment). Electrolyte concentration per liter: Na+ 154 mEq; Clˉ 154 mEq (not including ions for pH adjustment).
The solutions contain no bacteriostat, antimicrobial agent or added buffers (except for pH adjustment) and are intended only for single-dose injection. When smaller doses are required the unused portion should be discarded.
10% LMD (dextran 40) is an artificial colloid pharmacologically classified as a plasma volume expander; 5% Dextrose Injection is a fluid and nutrient replenisher; 0.9% Sodium Chloride Injection is a fluid and electrolyte replenisher.
Dextran 40 is a linear glucose polymer (polysaccharide) chemically designated (C6 H10 O5)n.

AVAILABILITY

Limited Inventory: 0409-7418-03Additional Information: See below for more information regarding specific products. View additional information and potential alternatives.